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Science News: Quality of Life in Inflammatory Neuropathies: The IN-QoL

Submitted by Francisco E. Gomez, MD, News Science Editorial Board
Edited by Lisa M. Williams, MD, News Science Editorial Board

Draak THP, Faber CG, Merkies ISJ. Quality of life in inflammatory neuropathies: the IN-QoLJ Neurol Neurosurg Psychiatry. Published Online First: 06 October 2017. doi: 10.1136/jnnp-2017-316634

While there is a multitude of quality of life (QoL) questionnaires developed for chronic diseases, to date, there is no consensus on which questionnaire is best suited to assess QoL in inflammatory neuropathies. This study used an international cohort involving 264 patients diagnosed with GBS, CIDP, IgM monoclonal gammopathy related polyneuropathy (MGUSP) and Multifocal Motor Neuropathy (MMN) to establish a new disease-specific questionnaire in inflammatory neuropathies (IN-QoL). The cohort completed six commonly used questionnaires including the WHO quality of life scale (WHOQoL BREF), Sickness Impact Profile, EuroQoL scale, Nottingham Health Profile, short form 36-item health survey (SF-36) and Vickrey Peripheral Neuropathy Quality-of-Life Instrument-97. Investigators then applied statistical methods including Rasch analysis to the pooled 324 questions, determining a final questionnaire which was slightly reliable, valid and responsive. The IN-QoL proved to be multidimensional requiring two subsets termed the In-QoL-mental and IN-QoL functional. However, when correlated with the patient’s visual analogue scale using the Euro-QoL-health quality visual analogue scale (EQ-VAS) the mental subset had a higher correlation. A higher responsiveness rate was associated with patients with acute disease such as GDP as opposed to more indolent diseases such as MGUSP or MMN.  

Comment: The IN-QoL is a novel questionnaire evaluating reported QoL in inflammatory neuropathies and, in combination with the EQ-VAS, may be a useful assessment of QOL.

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